Medford Police reported attic fire.  Engine 1 advanced attack line to attic while Ladder 1 conducted primary search for two possible victims.  Second Alarm struck,  Ladder 2 to roof for ventilation.  Engine 5 crew to attic to relieve Engine 1 crew  and Engine 2 crew to the basement to shut down utlilities. After extensive search it was reported to Command that the 2 possible victims were not at home at the time of the fire.  Fire contained to attic area with smoke and water damage to the second floor.